- Driatan17 as Blossom, Bubbles, & Sedusa
- Talim0BS as Buttercup, Poochi, & Lil Arturo
- PowerpuffOldandZfan as Mojo Jojo, Him, Cody, Monster Cody, Brick, & Pancho
- OreimoAbridgedSeries as Professor Utonium
- 6SeptaG - The Abridging Agent as Ken Utonium
- ToshikiNightfox as the Mayor, Gigi the Great, Fuzzy Lumpkins, & Top Hat
- 0NeverNeverLand0 as Ms. Sara Bellum
- PrincessofAnime1100 as Boomer & Ms. Keane
- MelissaHoll149 as Annie & Princess Morbucks
- VileKaizer as Butch
- Mr666gothica as Ace, Big Billy, & Grubber
- RAnimeFreak as Violet
- ThePagesAreViral as Ivy
- KittyKyun as Kasey (Blossom's Younger Sister), Duchess Morbucks, & Bubbles' Grandmother
- PurpleMokona101 as One of Princess's Friends & Various Characters
Episode 1 - Spank the Monkey (Complete)
Episode 2 - Bubbled Chaos (Complete)
Episode 3 - The Bisexual Tomboy Heroine (Yet to be released)
Episode 4 - Monkey See, but Doggie Do Nothing (Yet to be released)
Episode 5 - Mojo Jojo's Bizarre Adventure (Yet to be released)
Episode 6 - Fuzzy Lumpkins, I Choose You! (Yet to be released)
Episode 7 - WTF's with the Afro?!! (Princess Episode) (Yet to be released)
Episode 8 - Johnny Cosmo: The Priss of the Future (Yet to be released)
Episode 9 - Whose Line Is It Anyway? (Amoeba Boys Episode) (Yet to be released)
The Powerpuff Girls ZEdit
Blossom is obsessed with three things: Anime, sweet foods, and boys. Blossom is depicted as the leader of the team. Due to Blossom's love for anime, manga, & abridged series, she often comes off as a nerd at random moments. Her favorite abridger is ShadyVox because she thinks he's hot. She lives with her two parents, the both of which are always arguing with each other, & her younger sister Kasey, whom of which is more of a nerd than Blossom is.
Her transformation theme song is I'm a Super Girl
Bubbles is sweet, innocent, bubbly, & a little bit psychotic. She constantly switches from a sweet little girl to a girl bent of enslaving the citizens of New Townsville. She lives with her grandmother, who is just like Bubbles & thinks that she is a witch & tries to perform witch craft to help Bubbles to enslave the world. She owns a stuffed octopus doll called Octi, which is actually possessed and she & Octi have little conversations on how to enslave all of the world. The only things that can tame Bubbles' evil ways is her Octi doll, if it's possessed by a much more powerful & more evil being (Him), & Cody, being her one and only love interest.
Her transformation theme song is Tsukema Tsukeru performed by Hatsune Miku
Buttercup is the tomboy of the group. She is also a secret bisexual. She has no shame in letting people know that she likes boys, but she tries to keep it secret that she is also into girls. She & Blossom end up having arguments every now & then, but Buttercup is actually in love with Blossom & she is too afraid to tell her so. She lives with her mother, her older & younger brothers, and her father, whom of which is the famous masked wrestler, The Flying Pansy.
Her transformation theme song is the City Escape Remix from Sonic Generation
- The song used in the opening credits is Melt by Hatsune Miku.
- Every character in the show keeps their names given to them in the English Dub, but some of the characters maintain their characteristics from the Japanese version. For example, Cody will have a much more serious disease than whatever the character's ailment (illness) is in the English Dub.
- Mojo Jojo's characteristics & voice are both styled from the original version created by Powerpuff Girls creator Craig McCracken & voice actor Roger L. Jackson.
- Originally, Toshikinightfox's inspiration for the Mayor's voice was going to be in the style of Family Guy's Ollie Williams.
- Episode 2 is the first time PowerpuffOldandZfan has attempted to lip-sync an entire episode. However, due to technical & personal reasons, the second half of the episode did not include lip flaps.
- In Episode 1, Bubbles is humming a song originally made by DriatanVA called "Dria's Bored Song". This is a reference to DriatanVA voicing the character.
- When Blossom eats the cookie in Episode 1, the sound she makes while eating the cookie was actually a blooper sound made by DriatanVA.
- After episode 2, PowerpuffOldandZfan will continue to make the series, but has decided not to edit lip flaps in the rest of his videos, including other abridged projects such as Venus Versus Virus Abridged. He will, however, be willing to edit sound effects & music and give the position of lip flap editing to someone else. As to who that will be is currently unknown.