- Driatan17 (now known as Dria-dono) as Blossom, Bubbles, & Sedusa
- Talim0BS as Buttercup (First Voice), Poochie (First Voice)
- Emma Andstuff as Buttercup (Second/Current Voice) & Poochie (Second/Current Voice), & POSSIBLY Lil Arturo
- PowerpuffOldandZfan as Mojo Jojo, The Narrator, Him, Cody, Monster Cody, Brick, & Pancho
- OreimoVA as Professor Utonium
- 6SeptaG - The Abridging Agent as Ken Utonium (First Voice)
- AyaChan993 as Ken Utonium (Second/Current Voice)
- ToshikiNightfox as the Mayor, Gigi the Great, Fuzzy Lumpkins, & Top Hat
- 0NeverNeverLand0 as Ms. Sara Bellum
- PrincessofAnime1100 as Boomer & Ms. Keane
- MelissaHoll149 as Annie & Princess Morbucks
- DesuNoteVA as Kasey (Blossom's Younger Sister) and Ken Utonium's Mother [X-Mas Special]
- PowerpuffOlandZfan as Bubbles' Grandmother [X-Mas Special]
- GaoGaiKingtheGreat as Johnny Cosmo [Episode 5]
- SpiritKitten as a Female Student [Episodes 3 & 4]
Unknown for continuation:
(These are people that were given a role in the series, but due to lack of contact, it is unknown if they still wish to be a part of the series.)
- VileKaizer as Butch
- Mr666gothica as Ace, Big Billy, & Grubber
- RAnimeFreak as Violet (member of the Amoeba Boys)
- ThePagesAreViral as Ivy (anime version of Snake)
Episode 1 - Spank the Monkey (Complete)
Episode 2 - Bubbled Chaos (Complete)
Episode 3 - Uh... The Green One (Complete)
Episode 4 - Episode 3 the Sequel Part 2 (Complete)
Special Episode: PPGZA Christmas Special
Episode 5 - Cosmo Cowardice (Johnny Cosmo Episode) (Complete)
Episode 6 - A Wild Lumpkins Appears! (Fuzzy Lumpkins Episode) [Script Written]
Potential Future Episodes:
(The order in which these episodes will appear in the actual series may vary)
Monkey See, but Doggie Do Nothing (Yet to be released)
Mojo Jojo's Bizarre Adventure (Yet to be released)
WTF's with the Afro?!! (Princess Episode) (Yet to be released) (Being written) [POSSIBLY Ep 7]
Whose Line Is It Anyway? (Amoeba Boys Episode) (Yet to be released)
Sedusa Episode (Yet to be released) (Being written) [POSSIBLY EP 8]
Gigi the Great Episode (Yet to be released)
Gangreen Gang Episode (Yet to be released)
Rowdyruff Boys Z Abridged (Yet to be released)
The Powerpuff Girls ZEdit
Blossom is an otaku that is overly obsessed with anime, tokusatsu, & boys. She's also incredibly goofy & acts incredibly silly at random moments.
(PowerpuffOldandZfan is thinking about adding more to Blossom's character within the series. One potential idea is that she constantly in on/off relationships with boys that dump her for reasons that are usually her own fault)
Blossom's real name in the abridged series is Kelly
Despite her cute & innocent appearance, Bubbles is murderous psychopath that wishes to take over the Earth with her new powers. She owns a stuffed octopus doll called Octi, which is actually possessed by an evil spirit. The only things that can tame Bubbles' evil ways is her Octi doll, if it's possessed by a much more powerful & more evil being (Him), & Cody, being her one and only love interest.
Bubbles' real name in the abridged series is Michelle
Buttercup is the tomboy of the group & a secret bisexual. She has no shame in letting people know that she likes boys, but she tries to keep it secret that she's also into girls. Buttercup is deeply in love with Blossom, despite how many times they argue with each other, & she is too afraid to express her true feelings towards her.
Buttercup's real name in the abridged series is Jo, which is short for Josephine
- The song that was used in the opening credits was originally Melt by Hatsune Miku. Now it is a shortened version of the 2nd intro to the original anime, "JIG THE UPPER".
- Every character in the show keeps their names given to them in the English Dub, but some of the characters maintain their characteristics from the Japanese version. For example, Cody will have a much more serious disease than whatever the character's ailment (illness) is in the English Dub.
- Mojo Jojo's characteristics & voice are both styled from the original version created by Powerpuff Girls creator Craig McCracken & voice actor Roger L. Jackson. At the same time, the voice of the Narrator is styled from the original version voiced by Tom Kenny.
- Originally, Toshikinightfox's inspiration for the Mayor's voice was going to be in the style of Family Guy's Ollie Williams.
- Episode 2 is the first time PowerpuffOldandZfan has attempted to lip-sync an entire episode. However, due to technical & personal reasons, the second half of the episode did not include lip flaps.
- In Episode 1, Bubbles is humming a song originally made by DriatanVA called "Dria's Bored Song". This is a reference to DriatanVA voicing the character.
- When Blossom eats the cookie in Episode 1, the sound she makes while eating the cookie was actually a blooper sound made by DriatanVA.
- It took PowerpuffOldandZfan over a year to complete episode 2 due to technical issues.
- Sonic the Hedgehog, Metal Sonic, & the Old Owl from the Sonic Abridged OVA Movie make brief cameo appearances in episode 2. The Sonic Abridged OVA Movie was PowerpuffOldandZfan's first official abridged project.
- In episode 3, while trying to guess the Mayor's occupation (other than Mayor), Bubbles makes a guess by saying, "Or a barber that kills his victims when they're not looking?". This is an obvious reference to Sweeny Todd: The Demon Barber of Fleet Street.
- The decision to give the girls REAL names to their alter egos was due to the fact that, in the English Dub of the original anime, the girls have their super hero names as their real names. For Example: In the JP version, Blossom's real name is Momoko. But in the English Dub, her name is Blossom for both her super hero name & her real name.
- Episode 4 of PPGZA is, by far, the shortest episode in the series. With the first three episodes being around 10-12 minutes long & episode 4 only being around 4 minutes & 32 seconds long. This part was intended to be part of episode 3, but was separated into its own episode because episode 3 would've been longer than originally intended.
- When thinking of a name for episode 1 of the series, PowerpuffOldandZfan did not know what the phrase "spank the monkey" meant at the time.